A wide-ranging group of new books and articles have recently been published challenging the efficacy of the enormously popular new generation of anti-depressant medicines, the SSRI's (Selective Serotonine Reuptake Inhibitors), which include Prozac. One of the most popular medications in the country, Prozac is currently the third-most-common prescription drug taken in America.
Siddhartha Mukherjee, assistant professon of medicine at Columbia University, in a recent New York Times artictle, called it "the new villain of modern psychopharmacology - overhyped, overprescribed, chemical sympotmatic of a pill-happy culture searching for quick fixs for complex mental problems".
Two books that are raising these issues are, "The Emperor's New Drugs" by pyschologist Irving Kirsch, "Let Them Eat Prozac", by David Healy, to name just a few. The use of these drugs and for so many people is being challenged on many levels, not the least being (1)"the very theory (the serotonin hypothesis) for how these drugs work" and (2) the "slippery, seemingly-contradictory studies" that suggested that 75 - 82% of an antidepressant' effect could have been obtained merely by taking a placebo. Many researchers concluded that "pharmaceutical companies were exaggerating the benefits of antidepressants by selectively publishing positive studies while suppressing negative ones".
Mukherjee goes on to cite research done in 2010 when the placebo effect data was reevaluated using six of the most rigorously conducted on antidepressants. The findings vindicated the early research conclusions for the most part. First, patients with severe depression tend to respond most meaningfully to antidepressants while those with moderate to mild depression do not. Second, serotonine probably plays an important role, but not fully understood fully, in cases of severe depression. Third, the "brain-as-a chemical-soup" theory was "far too naive".
The author describes much of the new research that is being done. Many are wondering whether depression might have multiple subtypes - with some responding to treatment with serotinin-enhancing drugs and some not. Also, could depression be another kind of neurological disorder in which the illness is precipitated by the death of neurons in certain parts of the brain? A sort of degenerative disease - like Alzheimers or Parkinson's - sort of a "dementia of the mood?" Depression may be "emotional pain with context", some believe. The role of the hippocampus may be to help put the situation with an emotional component into context. If the hippocampus is working properly, it may act as a conduit to tell our conscious brain, for expample, that the loss of love should be experienced as sorrow or the loss of a job as anxiety.
All in all, the author says, "depression is a complex, diverse illness, with different antecedent causes and manifestations." None of the new theories explain why "talk therapies" work (and the research shows they indeed do) and in some patients and not in others. Or "why the combination of talk and antidepressants seems to work consistently better than either alone".